Endocrinology of the Testis and Male Reproduction
This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction, and male infertility. In addition, sociodemographic, psychological, and ethical aspects of male reproductive disorders are discussed. The book is intended as a major reference for endocrinologists, andrologists, and sexologists, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
Over de auteurManuela Simoni, MD, PhD, is Full Professor of Endocrinology and Deputy Director, Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, Italy. She is also Director of the Unit of Endocrinology, Azienda USL of Modena, Italy and Director of the School of Specialization in Endocrinology and Metabolism, University of Modena & Reggio Emilia. She was previously University Professor of Endocrinology and Molecular Biology of Reproduction at the University of Munster, Germany. Dr. Simoni is current Secretary of the European Society of Endocrinology and from 2010 to 2014 was a member of the Executive Council of the Italian Society of Andrology and Medical Sexology. She is a past Associate Editor of Human Reproduction and past Senior Editor of the Journal of Molecular Endocrinology, and she is a current editorial board member of the European Journal of Endocrinology and Molecular & Cellular Endocrinology. She is the author of 167 papers in journals listed in PubMed, as well as more than 60 book chapters, and has an H-index of 52. Ilpo Tapani Huhtaniemi, MD, Dr. Med. Sci. (PhD), is Professor of Reproductive Endocrinology, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London, UK. Prior to taking up this position in 2002, he had been Professor and Chairman of Physiology at the University of Turku, Finland for more than 15 years. Dr. Huhtaniemi has been the recipient of many awards and honors, including most recently the Egon Diczfalusy Foundation Lifetime Achievement Award (2014) and the Iain Macintyre Medal from The William Harvey Research Institute, Queen Mary University, London, UK (2015). He has been Chief Editor of Molecular and Cellular Endocrinology since 1999 and is also past Editor of various other leading journals. He is a past president of the International Society of Andrology and has been a member of the WHO Special Programme of Research, Development and Research Training in Human Reproduction since 1987. He is the lead or co-author of approximately 650 peer-reviewed papers and has an H-index of 70.
InhoudPart I Physiology of the hypothalamus-pituitary-gonadal axis, the testis, and testicular function: Control of GnRH secretion.- GnRH action .- Gonadotropins.- Gonadotropins receptors.- Sex determination.- Sexual differentiation.- Fetal testicular function (Testosterone, AMH, INSL3).- Testis development and descent.-Functional anatomy and histology of the testis .-Testicular steroidogenesis and testosterone.- Androgen actions - androgenic - anabolic ? (including testosterone metabolism DHT, E2).- Androgen receptor.- Spermatogenesis (including endocrine and paracrine control.- Epididymal sperm transport and fertilization .- Part II Clinical approach to the disorders of male reproduction: Anamnesis and physical examination .- Hormonal laboratory examination.- Genetic analysis .- The semen analysis .- Imaging in andrological examination .- Histopathological evaluation of the testis .- Part III Disorders of sexual development and male hypogonadism: Disorders of sexual development .- Classification and epidemiology of hypogonadism.- Clinical manifestation and diagnosis of androgen deficiency .- Primary and secondary hypogonadism.- Delayed puberty .- Androgen resistance .- Estrogen deficiency.- Hypogonadism in systemic diseases .- Effect of cancer treatments on testicular function.- Gynecomastia.- Late-onset hypogonadism .- Treatment of hypogonadism .- Part IV Male infertility: Male infertility .- Genetics of male infertility .- Immunological aspects of infertility .- Rational treatment of male infertility .- Empirical treatment of male infertility .- Varicocele .- Assisted reproduction for male infertility .- Intra-testicular sperm extraction.-- Cryopreservation of spermatozoa.- Therapy with anti-androgens .- Part V Miscellaneous aspects: Male contraception .- Use and abuse of androgens .- Socio-demographic aspects of male reproductive disorders.- Psychological aspects of male infertility.- Ethical aspects of male reproductive disorders and their treatment .